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KMID : 1140420170260040274
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Journal of Obesity & Metabolic Syndrome
2017 Volume.26 No. 4 p.274 ~ p.280
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Dietary Calcium Intake May Contribute to the HOMA-IR Score in Korean Females with Vitamin D Deficiency (2008?2012 Korea National Health and Nutrition Examination Survey)
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Kim Jin-Ho
Lee Seok-Hoon
Park Soo-Jung
Yeum Kyung-Jin
Choi Beom-Hee
Joo Nam-Seok
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Abstract
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Background: Vitamin D and calcium are important factors involved in the regulation of blood glucose and insulin secretion. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score is a useful variable for evaluating insulin resistance, and therefore we cross-sectionally compared HOMA-IR scores according to serum vitamin D levels and dietary calcium intake.
Methods: We selected data from healthy males (n=5,163) and females (n=7,506) analyzed over 5 years (2008?2012) via the Korea National Health and Nutrition Examination Survey (KNHANES). We calculated HOMA-IR scores and compared them according to serum 25-hydroxyvitamin D (25(OH)D) concentration classification (<20, 20?30, >30 ng/mL) and dietary calcium quintile after adjustment for relevant variables using complex sample analysis. Comparisons were done after data weighting.
Results: The mean dietary calcium intake in males and females was 558.1 mg/day and 445.9 mg/day, respectively. The mean serum 25(OH)D concentration in males and females was 19.4 ng/mL and 16.8 ng/mL, respectively. After adjustment for relevant variables, HOMA-IR score was significantly correlated with serum 25(OH)D concentration and dietary calcium intake in females, whereas it was only correlated with serum 25(OH)D concentration in males. HOMA-IR was significantly lower in the top quintile of dietary calcium intake (mean, 866 mg/day) within females with vitamin D deficiency (P=0.047).
Conclusion: Adequate dietary calcium intake may be important for normal HOMA-IR in females with vitamin D deficiency.
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KEYWORD
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Insulin resistance, Vitamin D, Calcium
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